This Printer's Proof is signed in a vertical format however, the edition of 50 is a horizontal format, with the circular image in the upper right. After this print was signed the artist must have decided to print it horizontally.
The subject of this lithograph is the Greek myth of Sisyphus, who was condemned by the gods to forever roll a huge stone up a mountain, only to have it roll back to the bottom each time he reached the summit.
Namesake, academic Theodore Roszak commented that the myth represents to modern society: "a project any less grotesquely absurd than the labor of Sisyphus taking his stone up the hill."