After the poster advertisement for Poudre Bleue (Blue Powder) antiseptic powder, designed by French painter and graphic artist Firmin Bouisset (1859-1925). The text loosely translates to: "Family-size antiseptic blue powder, prepared according to the Pasteur method. Infallible cure. Microbial diseases. Nose, Ears, Eyes."
This advertisement heralds the beginning of the wide-spread acceptance of anaesthetic theory. Prior to the 1860s, one was more likely to die from infection after an otherwise successful surgery than on a battlefield, and with the onset of the Civil War and other deadly battles, many doctors and scientists were eager to find a cure. Studies by surgeon Joseph Lister (Scottish: 1827-1912) and microbiologist Louis Pasteur (French: 1822-1895) led to the theory of germs, and of their irradication through direct application of a substance and by creating a sterile surgical environment to help improve chances of survival. In the 1890s, iodized compounds and powders with calcium carbonate were among the earliest form of antiseptic available for purchase to the public.