Painter, printmaker, and stained-glass artist Jos Hendrickx was born in Borgerhout, Belgium, on March 13, 1906, the second of what would ultimately be thirteen children. Showing an early interest in art, he began taking classes at the Royal Academy of Fine Arts in Antwerp while still in his teens. This went against his father's wishes and he therefor had to support himself as a dockworker. While at the Academy he studied under Jan De Graef, Walter Stevens, and Eugeen Van Miegham.

In 1925 at age nineteen he was accepted into the National Higher Institute of Fine Arts, Antwerp. Among his professors were Isidore Opsomer, with whom he studied figure drawing and painting, and Eduard Pellens, with whom he studied engraving. He moved to in Paris in 1930 but had to return to Belgium when his father died the following year. 

After settling once more in Belgium, he focused on images of flora and of architecture, executing a series of drawings titled "Tree and Greenhouses." He became a member of the Jonge Pilgrim group which promoted Christian art and the helped to develop the Animism art movement, which focused on the spiritual. However, his interest in the avent-garde, likely sparked by his time in Paris, set him somewhat appart from his peers. He opened his own studio in Berchem in 1936 and began exhibiting in Belgium and internationally. Among his first major commissions was forty woodengravings on the life of Saint Francis for the 1937 Paris World's Fair. 

Hendrickx received commissions for stained glass windows in various churches and chapels in Belgium, including a ninteen-panel series for the parish church of St. Remigius in Baarle-Hertog.

In addition to his fine art career, he was a teacher at the Secondary Vocational and Industrial School on Beveren from 1938 to 1946, teaching practical and free-hand drawing. He then took a post at the Royal Academy of Fine Arts, Antwerp, where he taught drawing, graphic arts, and poster design from 1946 to 1952. From 1951 until his death, he taught was a professor of etching and engraving at the National Higher Institute of Fine Arts. In 1949 he purchased the former Van der Biest Almshaus, where he remained for the rest of his life. It was there that he was able to complete larger stained-glass projects, executing the entire process himself. Jos Hendrickx died in Antwerp on November 16, 1971.

Hendrickx's work is held in the collections of the Royal Museums of Fine art in Antwerp and Brussels, and in instutions in France, Germany, and the United States. He received awards for his work in shows in Warsaw (1933), Chicago (1938), Lugano (1954), Leipzig (1965), and Krakow (1968). Recognitions included an honorary membership to the Accademia delle Arti del Disegno di Firenze, and inclusion as a corresponding member of the Royal Academy of Sciences, Letters, and Fine Arts of Belgium on the suggestion of Marc Severin.